Install the app
Antihistamines and dementia. In two separate large population .
Antihistamines and dementia. One reader shared this concern: Q. "As a result, over time, regular use has been linked to cognitive decline and an increased risk of dementia. In the realm of common over-the-counter medications, Benadryl is a household name frequently turned to for relief from allergies, colds, and even insomnia. ZzzQuil is diphenhydramine, the same as Benadryl. "If you take diphenhydramine, also known as Benadryl or any type of antihistamine for a long time it has been linked to dementia," he explained. The risk grows with higher dose, longer use, advancing age, and the number of anticholinergic medicines taken together. If you're among the many who rely on this medication for a good night's sleep or a respite from allergies, you may be wondering: Is Is the risk of dementia among persons 55 years or older associated with the use of different types of anticholinergic medication? In this nested case-control study of 58 769 patients with a diagnosis of dementia and 225 574 matched controls, there Antihistamines Antihistamines, which have the active ingredient diphenhydramine, used for treating allergies, can spike the danger of faster dementia. This is concerning since recent studies show that one of the most common of those drugs—Diphenhydramine, the active ingredient in Benadryl—could lead to serious health problems, including dementia. Aug 8, 2024 · Benadryl and Alzheimer’s Disease: What We Know While dementia is a broad term encompassing various cognitive disorders, Alzheimer’s disease is the most common form of dementia, accounting for 60-80% of cases. Given that the potential adverse effects of the antihistamine with anticholinergic effects, there is growing interest in the association between antihistamine usage and the risk of dementia. Antiparkinson medicines are used to treat Parkinson's disease. However, what kind of antihistamine you’re taking can make a big difference to your long-term health. Some of us need antihistamines and may need them chronically. The disorder blights the lives of millions worldwide, slowly robbing them of their memories and Certain antihistamines found in common allergy medications and sleep aids are liked to an increased dementia risk. Aug 1, 2024 · H1 antihistamines (AHs), categorized as first-generation antihistamines (FGAs) or second-generation antihistamines (SGAs), possess anticholinergic properties linked to heightened dementia risk. However, recent research has raised concerns about their potential impact on memory and dementia risk, especially when used long-term. Writing on Certain antihistamines found in common allergy medications and sleep aids are liked to an increased dementia risk. In addition, some sleep aids available without a prescription can leave you feeling groggy and unwell the next day. The researchers looked at drugs which have an ‘anticholinergic’ action – meaning they block the action… Feb 9, 2016 · Studies have linked certain drugs to memory loss. Clinical studies reveal a 47% higher dementia risk among seniors who regularly use these medications. His worry It is the first study to show a dose response: linking more risk for developing dementia to higher use of anticholinergic medications. Medical professionals recommend using the lowest effective doses of antihistamines or opting for alternative treatments, as certain allergy medications may negatively impact brain health May 30, 2025 · Certain antihistamines found in common allergy medications and sleep aids are liked to an increased dementia risk. Studies have suggested that medications with anticholinergic properties, like Benadryl, might be linked to an increased risk of dementia. Apr 29, 2025 · 4. 2015 JAMA Internal Medicine Study: Researchers followed over 3,000 older adults for more than seven years. Antihistamines are commonly used medications that help relieve allergy symptoms and aid in sleep. Jun 24, 2019 · This nested case-control study including 58 769 patients diagnosed with dementia and 225 574 matched controls 55 years or older evaluates whether, and to what extent, anticholinergic drug exposure was associated with dementia risk. But here’s the twist: researchers have raised concerns about whether long-term or frequent use of drugs like Benadryl could be linked to memory problems — or even dementia — especially in older adults. The drugs include many popular prescription and over-the-counter medications. Diphenhydramine (e. May 22, 2013 · Further down the article states that medications like Benadryl and Vistaril are examples of antihistamines that may cause memory loss. Drowsiness is a well-known side effect of the drug, so many people use it precisely because it puts them to sleep. Antipsychotics treat psychosis. Mar 2, 2015 · Is your antihistamine bad news for your brain? Regularly taking a certain class of over-the-counter or prescription drugs might increase your risk for developing dementia down the line, finds a Jun 11, 2025 · Benadryl may have negative short and long-term effects for people with Parkinson’s disease, including an increased risk of confusion, hallucinations, and dementia. Antihistamines are frequently administered to psychiatric patients for a variety of purposes. In addition to treating allergy and cold symptoms such as sneezing and watery eyes, it also blocks the actions of acetylcholine. This systematic literature review and meta‐analysis aimed to assess the impact of ≥3 months of exposure to anticholinergics as a class on the The increased risk for dementia that remained consistent across anticholinergic subclasses is worth noting, with an increased risk found for people with high use of anticholinergics other than antidepressants, such as first-generation antihistamines and bladder antimuscarinics. Jun 16, 2025 · Second-generation antihistamines, such as cetirizine (Zyrtec), fexofenadine (Allegra), and loratadine, might increase the risk of dementia by blocking a particular brain neurotransmitter or increasing brain inflammation. Jan 27, 2015 · A new study shows a strong link between commonly used anticholinergic drugs and later dementia, with even sporadic use linked to cumulative risk. Aug 1, 2025 · Certain allergy medications, particularly first-generation antihistamines like diphenhydramine (Benadryl®), could negatively impact brain health and elevate dementia risk. ). © OsakaWayne Studios - Getty Images Nov 30, 2024 · 1. Research indicates that anticholinergic properties in certain antihistamines may contribute to cognitive decline and increase the risk of Alzheimer’s disease. 6 days ago · But experts believe it's time to say goodbye because of how older antihistamines like Benadryl cross the blood-brain barrier, causing grogginess and increasing the risk of falls, car accidents and potentially even dementia. The class of medications Antihistamines (AHs) are the most widely long-term therapeutic option to manage allergic diseases. Each bar above is scaled the increase of risk for anticholinergics of each class. Moreover, FGAs exhibit a higher dementia risk compared with SGAs. 1 What do these drugs all have in common, what do you need to know about them, and are there really risks to taking them? The drugs in Jan 26, 2015 · A large study links a significantly increased risk for developing dementia, including Alzheimer's disease, to taking commonly used medications with anticholinergic effects at higher doses or Jul 11, 2025 · Concerns about dementia risk lead many individuals to adopt healthy lifestyle practices, such as balanced diets, regular exercise, quality sleep, and mental engagement. There are two main types of antihistamines Mar 4, 2020 · Acetylcholine Acetylcholine is the neurotransmitter used by the brain for cognition and short-term memory. These medications include a variety of drugs, including antihistamines (like Benadryl), some antidepressants, and drugs that help people with Parkinson’s. While research on antihistamine use and dementia risk remains inconclusive, some studies indicate potential hazards. Prior studies often rely on crude exposure measures (use vs. Harvard Health suggests weighing the benefits and risks of antihistamines and using the lowest dose possible. Apr 6, 2023 · Benadryl (diphenhydramine) affects the body in a few ways. Understanding these risks is crucial for making informed decisions about medication Jan 10, 2025 · Benadryl and Dementia - What Does the Research Say? Several studies focusing on anticholinergic drugs have sparked concern about the potential connection between Benadryl use and an increased risk of dementia. Feb 19, 2024 · H1 antihistamines (AHs), categorized as first-generation antihistamines (FGAs) or second-generation antihistamines (SGAs), possess anticholinergic properties linked to heightened dementia risk. However, recent research has raised concerns about their potential connection to an increased risk of dementia, particularly when used long-term. Some have strong anticholinergic effects. Because when it comes to brain health, long-term convenience may not be Understanding Benadryl and Its Impacts Benadryl contains diphenhydramine, an antihistamine that effectively alleviates allergy symptoms. Antihistamines work to block the chemical Nov 3, 2020 · oxybutynin and tolterodine (taken for an overactive bladder) diphenhydramine (a common antihistamine, as found in Benadryl). Research suggests that first-generation antihistamines (FGAs) are associated with a higher risk of dementia compared to second-generation antihistamines (SGAs) 6. Jul 9, 2015 · Higher dosage or long-term use of common drugs with anticholinergic effects is linked to significantly increased risk of dementia - including Alzheimer’s - says large study. Case-control study. They also turn to them if they have trouble falling or staying asleep. Feb 16, 2024 · It took me by surprise. They include tricyclic antidepressants like doxepin Feb 21, 2025 · A Harvard University expert has warned those with allergies to consider alternatives to antihistamines, following research linking the popular medication to a raised risk of dementia. . May 23, 2025 · Certain antihistamines found in common allergy medications and sleep aids are liked to an increased dementia risk. Charles Puza, and was picked up by BuzzFeed. Feb 22, 2025 · Antihistamines are commonly used medications that provide relief from allergy symptoms. Mar 9, 2021 · In a study update (21 studies) as of March 9 2021 anticholinergics have been determined to be a major cause of dementia. However, other medicines without anticholinergic effects are options for some people. Antihistamines Using hay fever medication regularly could be bad for your brain, Dr Hassad said. Certain antihistamines found in common allergy medications and sleep aids are liked to an increased dementia risk. This Nov 3, 2024 · Benadryl, a common over-the-counter medication, has been linked to cognitive decline and increased dementia risk, particularly in older adults. Sep 23, 2024 · Zyrtec's link to dementia explored, examining antihistamine effects on cognitive function, brain health, and potential risks of long-term use, clarifying concerns on allergy meds and dementia correlation. Mar 15, 2025 · Sleep aids that do not cause dementia, safest alternatives, risks of common sleep medications, and expert insights on cognitive health and sleep quality. Apr 18, 2016 · Some popular antihistamines have the ability to affect the brain in an unpleasant way. Sep 15, 2025 · The Journal of the American Medical Association links certain sleep medications with an increased risk of dementia. Researchers discovered a dose-dependent increase in dementia risk among antihistamine users, suggesting that prolonged use of these medications could potentially harm brain health. This concern stems from studies that have shown a possible association between the long-term use of antihistamines and an increased risk of dementia, particularly in older adults. Mar 3, 2025 · If you’re blighted by hay fever or other allergies, you probably rely heavily on antihistamines – one of the best medications to treat them – to ease your watery eyes, runny nose and sneezing. General practices in the UK contributing to the Clinical Practice Research Patients with allergic rhinitis on FGAs or SGAs face an escalating dementia risk with increasing cumulative dosage. And the longer the medications are taken, the greater the risk. Learn about a study that recently linked long-term use of Benadryl and dementia in adults who had taken it consistently over three years. Jun 2, 2025 · A commonly-used over-the-counter medication that can provide allergy and cold relief or serve as sleep aids may increase a person’s risk of dementia. Mar 27, 2024 · Benadryl, which contains diphenhydramine, is a drugstore mainstay and just one medication out of many that could possibly damage brain health. The findings are published in the British Medical Journal. May 30, 2025 · Over-the-counter antihistamines, commonly used for allergies, colds, and sleep, may increase the risk of dementia, according to recent studies. In addition, some of the drugs you may be taking to help you accomplish those things could increase your risk of dementia. Thoughts? Jun 29, 2025 · However, Benadryl’s medication class (anticholinergics) does appear to be associated with dementia. May 8, 2025 · They are supposed to make you feel better, but did you know some of the medicines in your cabinet could be putting you at risk for dementia? Apr 14, 2025 · Some antihistamines, commonly taken for hay fever, have been found to have a possible link with dementia Credit: Getty The common allergy tends to hit between March and September, when the pollen Apr 21, 2016 · Taking over-the-counter medications for colds, flu and allergies may seem harmless, but a new study warns that certain drugs are linked to an increased risk of dementia. Jun 23, 2024 · It has been suggested that long-term use of anticholinergics or medications with anticholinergic effects can increase the chances of developing dementia. Learn what the research says and what it means for older adults. Aug 2, 2019 · Figure 4: Dementia Risk for Antipsychotics, Incontinence Medications, Antidepressants, and Antihistamines. Boosting acetylcholine levels is an effective (and FDA-approved) method of treating dementia/Alzheimer’s. Prolonged use could raise risk of dementia "First-generation antihistamines, in particular, have anticholinergic effects , which means they block a neurotransmitter, which is important for learning," says Dr Sambyal. Older adults 50+ were more likely to hear the claim than […] Jun 2, 2025 · A commonly-used over-the-counter medication that can provide allergy and cold relief or serve as sleep aids may increase a person’s risk of dementia. Aims We performed a comparative A Harvard University expert has warned those with allergies to consider alternatives to antihistamines, following research linking the popular medication to a raised risk of dementia. , Benadryl®) is a first-generation antihistamine medication [1]. Feb 25, 2025 · Learn about the potential side effects of antihistamines in the elderly, including risks, safer options, and why caution is crucial for seniors. Benadryl and first-generation antihistamines are thought to increase risk of dementia through anticholinergic effects (this is also what causes dry eyes, dry mouth, etc. With safer, non-sedating antihistamines now widely available, doctors suggest reconsidering what’s in your daily rotation. Jan 20, 2020 · There’s mounting evidence supporting a connection between certain medications (anticholinergics and benzodiazepines) and dementia. Fast forward to 2024, and a study in the Journal of Allergy and Clinical Immunology also links Feb 24, 2025 · Research supporting the potential link between antihistamines and dementia includes a 2015 study that tracked the brain health of participants over 65 years old for nearly two decades. A new review published in the World Allergy Organization Journal urges a reevaluation of the drug’s safety, arguing its risks now outweigh Long-term use of certain first-generation antihistamines, such as diphenhydramine and hydroxyzine, may be associated with an increased risk of dementia, part Oct 2, 2024 · Antihistamines and dementia risk: exploring the link between long-term use of antihistamine medications, cognitive decline, and neurodegenerative diseases like Alzheimer's. non-use), lacking detailed analysis of anticholinergic effects across different cognitive domains indicative of dementia. Dec 7, 2020 · Episodic short-term memory and selective attention were unimpaired. g. Setting General practices in the UK contributing to the Clinical Practice Research Datalink. Jan 9, 2025 · Longitudinal studies suggest an association between anticholinergic exposure and risk of dementia. I recently heard that anticholinergic drugs can cause brain atrophy and may increase the risk for dementia. May 19, 2025 · Diphenhydramine, a common antihistamine found in over-the-counter allergy and sleeping medications, may increase users' risk for dementia when taken daily over a prolonged period. Jul 21, 2025 · NEW ORLEANS — Could frequent use of some cold and allergy medications, and many other common drugs, like those for anxiety, increase your risk of dementia? You may have heard the media coverage that common medications may increase the risk for dementia. Crawford said her mother’s geriatric physician believes her nightly use of a sleep aid contributed to her condition. What the study found regarding Benadryl and dementia Mar 23, 2025 · The potential link between antihistamines, particularly first-generation ones, and dementia has raised concerns regarding long-term cognitive health. The neuroleptic treatment of schizophre … Dec 10, 2024 · When used regularly, antihistamines may cause constipation, dry mouth and trouble urinating. Jun 25, 2025 · The relationship between antihistamine use and dementia risk is unclear, with studies yielding mixed results. Benadryl® and some other antihistamines contain diphenhydramine, which is used to treat symptoms caused by allergies, hay fever and colds. Dec 21, 2023 · The ongoing investigation into Benadryl’s role in dementia risk highlights a critical intersection between everyday medication use and long-term cognitive health. Mar 3, 2025 · Does this popular hay fever drug increase your dementia risk? Antihistamines are one of the best medications for hay fever, but some studies suggest they could be harmful for our brain health Jun 30, 2018 · Patients have asked me this allergy season whether antihistamines are safe to use because they either heard or read that antihistamines could cause dementia. In fact, according to new data presented at the American College of Nov 30, 2024 · The US scientist found a link between higher doses of some antihistamines and dementia. Benadryl still has some other side effects that can be harmful for A commonly-used over-the-counter medication that can provide allergy and cold relief or serve as sleep aids may increase a person’s risk of dementia. Participants 40 770 patients aged 65-99 with a diagnosis of dementia between April 2006 and July 2015, and 283 933 Mar 18, 2022 · Given that the potential adverse effects of the antihistamine with anticholinergic effects, there is growing interest in the association between antihistamine usage and the risk of dementia. But in recent years, murmurs have emerged suggesting a possible connection between Benadryl and dementia. Many people turn to over-the-counter medicines when they need relief from allergy and cold symptoms. However, neurological adverse events have been reported in post-marketing surveillance studies and there are limited literatures comparing the neurological disorders associated with newer-generation H1-antihistamines from real-world datasets. Louis adults reported hearing the claim in the last week, a 5% increase from the prior week; 93% believed it was true. Efforts to increase awareness among health care professionals and older adults about this potential medication-related risk are important to minimize anticholinergic use over time. Several large studies of schizophrenics have revealed an extremely high prevalence of Alzheimer's disease neuropathology compared with that in the general population. Jul 1, 2019 · Medically Reviewed Does Benadryl Cause Dementia? Long-term use of the drug has been associated with an increased risk of cognitive impairment and memory loss, but more research is needed. Antihistamines work to block the chemical histamine, which causes uncomfortable allergy symptoms. So it actually belongs to two classes of medications: antihistamines and anticholinergics. While it is incredibly helpful for short-term use, regular or long-term use might lead to unexpected consequences. Some research studies suggest that frequent use of anticholinergic medications may increase the chances of developing dementia. We must have optimal levels of acetylcholine to maximize our brain health. Anticholinergics include among others antidepressants and Benadryl. Nearly one in six (16%) St. Nevertheless, extensive clinical trials are imperative for confirming the association between FGA use, SGA use, and de … First-generation antihistamines: First-generation antihistamines such as diphenhydramine can cause many side effects in older adults, such as confusion, dizziness, drowsiness, blurred vision, sedation, difficulty urinating, constipation, and hypotension [17]. Caution should be exercised for long-term use of Benadryl (diphenhydramine), an antihistamine, and a non-benzodiazepine sedative-hypnotic, because of the association of increased risk for dementia. It is worth noting that the increased risk for dementia was consistent across anticholinergic subclasses, with increased risk found for people with high use of anticholinergic medications other than antidepressants, such as first generation antihistamines and bladder antimuscarinics. The longer you take them, the less likely they are to make you sleepy. Apr 25, 2018 · But it is important to choose wisely, as some allergy medications can harm brain health and increase dementia risk. Those of us with allergies, asthma, high IgE Jun 8, 2022 · Most sleep aids available without a prescription contain antihistamines. May 29, 2024 · The list of drugs linked to dementia includes anticholinergics and benzodiazepines, such as antihistamines, antidepressants, and anti-anxiety drugs. Writing on Apr 25, 2018 · Objectives To estimate the association between the duration and level of exposure to different classes of anticholinergic drugs and subsequent incident dementia. Higher cumulative anticholinergic use is associated with an increased risk for dementia. First-generation antihistamines such as diphenhydramine significantly impair cognitive tests, affecting mood, alertness, and psychomotor functioning. Short courses are rarely harmful, but anyone on daily therapy for more than a few weeks Dec 18, 2024 · Background H1-antihistamines are widely used to treat symptoms depending on histamine release in a variety of conditions. Antihistamines work to block the chemical To estimate the association between the duration and level of exposure to different classes of anticholinergic drugs and subsequent incident dementia. Sharon Burnham’s mother, Freda Crawford, has advanced dementia. This effect should be considered regarding the handling of concomitant medications in Alzheimer’s disease treatment trials. Yes, the evidence points to diphenhydramine and other anticholinergic medications, including pretty much all first-generation antihistamines, increasing the odds of developing dementia later in life. [1] I scrolled to the bottom to look through the article’s references for a link to the study in Neurology, but the article was not cited. Conclusion Treatment with 2 nd or 3 rd generation antihistamines may be associated with cognitive impairment, particularly in elderly patients. Feb 13, 2015 · February 13, 2015 Some drugs commonly used to treat hay fever, insomnia and depression have been linked to a higher risk of Alzheimer’s disease and other forms of dementia, a new study reports. Dec 7, 2021 · Does the antihistamine diphenhydramine (DPH) increase the risk of dementia? What about anticholinergic drugs for overactive bladder (OAB)? Jul 21, 2025 · NEW ORLEANS — Could frequent use of some cold and allergy medications, and many other common drugs, like those for anxiety, increase your risk of dementia? Jan 21, 2025 · Medications To Avoid In Elderly Patients First-Generation Antihistamines Diphenhydramine (Benadryl) and other first-generation antihistamines create substantial health risks for adults over 65. May 21, 2025 · Diphenhydramine is one of the most widely used first-generation antihistamines. com) Does Taking Antihistamines For Allergies Increase Dementia Risk? The relationship between antihistamine use and dementia risk remains unclear, with studies yielding mixed results. Antihistamines work to block the chemical 1 day ago · (Image Source: Pixabay. Mar 22, 2022 · Seniors who are experiencing cognitive disorders such as dementia and Alzheimer’s are also advised to stay away from first-generation antihistamines, as they can interfere with other medications. In addition to causing drowsiness they may actually do damage when taken for long periods of time. But there's one particular kind that could increase one's risk of dementia. Jan 4, 2005 · Newer Antihistamines May Cause Cognitive Impairment at High Doses By John Schieszer Physicians are generally told that second-generation antihistamines are causing less cognitive impairment than the first-generation agents, but some of the newer medications may produce impairment if used at or above the recommended doses. Mar 2, 2021 · If you're worried about developing dementia, you've probably memorized the list of things you should do to minimize your risk—eating a healthy diet, exercising regularly, getting adequate sleep, and keeping your mind and soul engaged. Apr 25, 2016 · A study found that anticholinergic agents for colds and allergies were associated with brain atrophy and dysfunction in older adults. Find out which medications can impair memory, cause sundowning and what alternatives exist. The 90-year-old lives at Castlewoods Place. This article explores the relationship between antihistamines and dementia development, providing important information for those who use these It’s not at all uncommon to have some Benadryl stashed in your medicine cabinet. It’s been FDA-approved since 1946 and remains a go-to remedy for everything from seasonal allergies to insomnia. Deborah Grayson took to TikTok to Jun 25, 2019 · Researchers did not find any increased risk of dementia with antihistamines, bronchodilators, muscle relaxants or medications for stomach spasms or heart arrhythmias. The study found a dose-dependent increase in dementia risk among antihistamine users. Feb 6, 2023 · Research suggests there may be a link between Benadryl and dementia. Dementia medications are often prescribed to manage symptoms, but understanding potential risk factors is crucial for prevention. Jan 28, 2015 · Common anticholinergic drugs like Benadryl linked to increased dementia risk Posted By Beverly Merz On January 28, 2015 @ 8:55 pm In Alzheimer's Disease,Drugs and Supplements,Mental Health | Comments Disabled One long-ago summer, I joined the legion of teens helping harvest our valley’s peach crop in western Colorado. Dec 13, 2024 · Research has shown a link between an increased risk of dementia and long-term use of Benadryl and other anticholinergic drugs that block acetylcholine, a neurotransmitter crucial for muscle Dec 21, 2024 · Dementia is a condition characterized by loss of memory and cognitive function. This article delves into the potential connection between Benadryl and cognitive impairment, exploring the underlying mechanisms and risk factors. These studies were done on those who took anticholinergics long term as many of us have. The study found a correlation between higher doses of anticholinergics and the development of dementia. Tolerance to the sedative effects of antihistamines can develop quickly. This research aimed to study the effects of long-term administration of AHs: on cognitive (memory, mood, attention, sleep and executive function) and May 29, 2025 · A commonly-used over-the-counter medication that can provide allergy and cold relief or serve as sleep aids may increase a person’s risk of dementia. Experts say the Caution should be exercised for long-term use of Benadryl (diphenhydramine), an antihistamine and a non-benzodiazepine sedative-hypnotic, because of the association of increased risk for dementia. Feb 29, 2024 · A recent TikTok video claimed that long-term use of Benadryl could increase your risk of dementia. In this new study, researchers collected detailed information from more than 300,000 adults ages 65 and older, and compared medication use among those diagnosed with dementia with those who were not. Pharmacists should discourage or limit the use of these drugs and suggest alternatives if possible. Design Case-control study. The concern stems from the Feb 16, 2025 · While Benadryl is certainly helpful for finding allergy relief in a pinch, experts say there could be some adverse long-term effects associated with its use—including an increase in dementia risk. Jun 25, 2024 · The primary outcome was the incidence of dementia, assessed using a Cox proportional hazard model, with adjustments for demographic characteristics and comorbidities. An expert discusses the latest research and what to do if you Long‐term treatment with anticholinergic agents may increase the risk of cognitive impairment or dementia. As researchers delve deeper, their findings are beginning to influence clinical practices and patient choices. But no study has looked specifically at Benadryl. Common prescription medications could be increasing your risk of dementia, a doctor has warned. Learn how anticholinergic drugs may cause this illness. Jun 27, 2025 · Long-term use of certain anticholinergic drugs—particularly first-generation antihistamines, bladder spasm drugs, and tricyclic antidepressants—can raise dementia risk by 10-50 %. Mar 1, 2025 · Antihistamines may have anticholinergic effects that could increase dementia risk, but the evidence is mixed and flawed. © OsakaWayne Studios - Getty Images Apr 24, 2025 · Benadryl, known generically as diphenhydramine, is a common over-the-counter antihistamine people use for allergies, colds, and sometimes even as a sleep aid. Low doses of these medications can help manage aggressive, irrational and compulsive behaviors that may develop in persons with dementia, more commonly with frontotemporal dementia or dementia with Lewy bodies. May 6, 2025 · A pharmacist has issued an urgent warning to hayfever sufferers over the daily use of certain antihistamines, claiming they could raise the risk of dementia. © OsakaWayne Studios - Getty Images Many people use over-the-counter sleep aids to help them rest better at night. Puza grew concerned when many of his patients confessed to regularly taking Benadryl, an old allergy medication, to help them sleep. May 29, 2024 · The Benadryl-Dementia Debate The concern surrounding Benadryl and other anticholinergic medications stems from studies suggesting a potential association between long-term use of these drugs and an increased risk of dementia in older adults. If you're on a deserted island and Benadryl is the only allergy drug available, you should take it, Wolfson said. Oct 23, 2024 · Growing evidence suggests long-term use of anticholinergic medications could harm your brain health and may raise your risk of dementia. Jul 1, 2025 · From the Research Association Between Antihistamine Use and Dementia Risk The relationship between long-term antihistamine use and dementia risk has been explored in several studies 6. Doctors share what you should take instead. The over-the-counter (OTC) antihistamine uses an active ingredient known as diphenhydramine to help the body What does this article add to our knowledge? Patients with allergic rhinitis receiving either first- or second-generation H1 antihistamines have an increased risk for developing dementia that increases with cumulative dosage. Antihistamines and Dementia: What’s the Link? In recent years, there has been growing concern about the potential link between antihistamines and dementia. However, data showed that individuals over 65 had a 78% higher risk of dementia Aug 11, 2025 · Benadryl (diphenhydramine), an antihistamine used to relieve allergy and cold symptoms, can cause some serious side effects, especially when taken incorrectly. Apr 26, 2018 · BMJ: Anticholinergic drugs and risk of dementia: case- control study UK researchers have found a link between the long-term use of certain anticholinergic drugs and an increased risk of dementia. Jun 23, 2025 · Although it’s unclear if taking doxylamine alone increases dementia risk, it may be wise to monitor your use of these antihistamines (histamine type 1 receptor antagonists) as you age. In two separate large population Jan 9, 2025 · In the rest of the body, it stimulates muscle contractions. Anticholinergic drugs include some antihistamines, tricyclic antidepressants, medications to control overactive bladder, and drugs to relieve the symptoms of Parkinson's disease. And it is also the first to suggest that dementia risk linked to anticholinergic medications may persist—and may not be reversible even years after people stop taking these drugs. The claim was made on TikTok by a very popular dermatologist, Dr. A 2022 study in Frontiers in Aging Neuroscience found no overall dementia risk in people over 50 who took these medications. arboe gicpeq vunw gxx puezfs dbjnu bzmai zfdclzqz quyyr hgdo